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Three Epochs in Managing VHL
figure to accompany Lamiell article, VHLFF, Sept 96
First Epoch, 1879-1928 No good description of VHL No treatments, no diagnostic tests
1864 Duschesne describes retinal angioma 1866 Mendel's laws of inheritance 1885 first internal combustion engine 1904 Von Hippel describes angiomatosis 1895 Roentgen discovers X-rays 1896 Frankel described pheo 1901 Tamanaki isolates adrenaline 1906 Morgan studies genetics of fruit fly 1909 First antibacterial drug 1909 Johanssen coined the term "genes" 1926 Lindau's report of 40 cases 1927 Mohler says VHL is hereditary 1927 First successful removal of a pheo
Second Epoch, 1929-1979 Better treatments, poor diagnostics
1929 Cushing's technique for controlling bleeding increase surgical survival 1933 Nobel prize for chromosome work 1941 Penicillin first used 1948 Gilles invention to control blood pressure and loss during surgery 1949 Nuremberg code of research ethics 1952 British invent amniocentesis 1953 Double helix model of DNA 1958 Ultrasound invented in Scotland 1961 First photocoagulation treatment 1964 Melmon & Rosen VHL overview 1971 Computed tomography introduced 1979 First recombinant DNA product
Third Epoch, 1979-2029 Imaging techniques for earlier diagnosis Work toward management & cure
1979 Fill et al. describe Hawaii family 1980 First attempt at gene therapy 1987 VHL gene is on chromosome 3p 1989 Enhanced MRI for VHL screening 1990 Human Genome Project began 1992 VHL Family Alliance founded 1993 Zbar et al map VHL gene to 3p25 1995 VHL protein binds to elongin B & C ?? Ways to constrain tumor growth ?? Chemical diagnostic techniques ?? Chemical ways to prevent tumors ?? Gene therapies to replace missing genetic material and cure VHL.
As published in the VHL Family Forum, 4:3, September 1996. For permission to reprint, please contact the VHL Family Alliance, editor@vhl.org. Further information is available from the VHL Family Alliance, info@vhl.org. |
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